You do not want to have your main traffic flow of people going to and from work to intersect with the traffic flow trying to leave the city. That’s why it is crucial that you do everything to separate this area from the main part of your new city. You can only afford to place one connection to the highway at the beginning, and how you make this connection will determine how heavy your traffic jams are going to be in that area until you have the money to rebuild it. Instead, here is the logic I use to set up and grow my cities in a somewhat realistic way.
Part of the fun of this game is building your town into the environment, using different environmental features to give “flavor” to your layout. I’m not going to give you a hard defined layout like many others do, because I think that takes away from the spirit of the game a little bit and no two cities I create are ever done in the same way. Which brings us to one of the most common questions revolving around this game, “What is the best starting road layout I can use?”. These leaves very little money for your roads. You don’t have a lot of initial funds to work with, and you need to get your power water and sewage setup. Starting off a new city in Cities: Skylines can be challenging, and one of the most difficult aspects of just starting off is setting up your roads.